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Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions

机译:倦怠和心血管疾病的风险:证据,可能的病因路径和有希望的研究方向

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摘要

Burnout is characterized by emotional exhaustion, physical fatigue, and cognitive weariness, resulting from prolonged exposure to work-related stress. The authors review the accumulated evidence suggesting that burnout and the related concept of vital exhaustion are associated with increased risk of cardiovascular disease and cardiovascular-related events. The authors present evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors. The association of burnout and vital exhaustion with these disease mediators suggests that their impact on health may be more extensive than currently indicated.
机译:长时间暴露于与工作有关的压力下,会导致精疲力尽,表现为情绪疲惫,身体疲劳和认知疲劳。作者回顾了积累的证据,这些证据表明倦怠和重要的力竭概念与心血管疾病和心血管相关事件的风险增加有关。作者提出的证据支持将倦怠与不良健康联系起来的几种潜在机制,包括代谢综合征,下丘脑-垂体-肾上腺轴失调以及交感神经系统激活,睡眠障碍,全身性炎症,免疫功能受损,凝血和纤维蛋白溶解,和不良的健康行为。倦怠和体力衰竭与这些疾病介体的关系表明,它们对健康的影响可能比目前所表明的更为广泛。

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