A ~(31)P, ~(13)C, and ~1H NMR Study of the Direct Interaction of Cocaine HC1 and Magnesium ATP

摘要

In vivo ~(31)P NMR studies recently have shown that cocaine causes an imbalance of the free magnesium in the brain which results in pH lowering, ischemia, and even death. This direct interaction with the free Mg~(+2) in the brain also affects the Ca~(+2) balance which controls arterial and vascular contraction. This research has addressed the mechanism of the cocaine interaction with magnesium adenosine 5-triphosphate (ATP) using ~(31)P, ~(13)C, and ~1H NMR using a Bruker 200 MHz nuclear magnetic resonance (NMR) system. Data are presented and discussed which shows that cocaine and ATP form a complex species which directly affects the NMR spectra.