Programmed cell death by interaction of ochratoxin A with other nephrotoxins

摘要

We determined the effects of co-exposure of OTA and other (potentially) nephrotoxic substances on renal tubule cells (IHKE, from the proximal tubule; MDCK-C7 cells, representing principal cells of the collecting duct) by measuring the activation of caspase-3, an enzyme with key roles in the process of programmed cell death or apoptosis.