Study on the dualistic mechanisms for dysregulated expression of in- terleukin 6 in multiple myeloma

摘要

Objective: To explore the source cells of interleukin-6 (IL-6) among bone marrow cells in multiple myeloma (MM). Methods Expressions of IL-6 in bone marrow mononuclear cells (BMMNCs) were detected us- ing double labeled immunofluorometry, and the IL-6 activities in the supernatants of co-culture system of myeloma cell line KM_3 and bone marrow stromal cells (BMCSs) were measured using B9 cell proliferation test. Results: IL- 6 molecules were expressed not only in cytoplasmic γ-globin positive cell but also in type I collage or von Wille- brand Factor (vWF) positive cells.