Loss of Expression of DNA Mismatch Repair Proteins in Aberrant Crypt Foci Identified In Vivo by Magnifying Colonoscopy in Subjects with Hereditary Nonpolyposic and Sporadic Colon Rectal Cancer

摘要

The aims of this study are to characterize the frequency, density, and distribution of aberrant crypt foci (ACF) and its histological features and to determine the frequency of loss of expression of DNA mismatch repair (MMR) proteins of subjects with hereditary nonpolyposic colorectal cancer (HNPCC) and sporadic colon rectal cancer (CRC).