A new signal processing algorithm based on a wavelet transform (WT) is proposed for instantaneous strain estimation in acoustic elastography. The proposed estimator locally weighs ultrasonic echo signals acquired before tissue compression by a Gaussian window function and uses the resulting waveform as a mother wavelet to calculate the WT of the postcompression signal. From the location of the WT peak, strain is estimated in the time-frequency domain. Because of the additive noise in signals and the discrete sampling, errors are commonly made in estimating the strain. Statistics of these errors are analyzed theoretically to evaluate the performance of the proposed estimator. The strain estimates are found to be unbiased, but error variances depend on the signal properties (echo signal-to-noise ratio and bandwidth), signal processing parameter (time-bandwidth product), and the applied strain. The results are compared with those obtained from the conventional strain estimator based on time-delay estimates. The proposed estimator is shown to offer strain estimates with greater precision and potentially higher spatial resolution, dynamic range, and sensitivity at the expense of increased computation time.
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