INVITED SESSION, SESSION 01: KEYNOTE LECTURES, Monday 4 July 2011 08:30 - 09:30

摘要

With the advent of the human genome project in the 1990s, DNA markers became available, allowing us to determine the parent and meiotic stage of origin of human aneuploid conditions. This approach has been extensively used to study the origin of trisomies, with one over-arching conclusion: the vast majority of clinically recognized trisomies derive from errors in the development of the egg and, in particular, from nondisjunction occurring in the first maternal meiotic division (MI). However, against this general background, it has also become apparent that there is considerable chromosome-to-chromosome variation, indicating that individual chromosomes behave differently with respect to mechanisms of meiotic nondisjunction.