Bone is a frequent site of metastasis for many cancers. Positron emission tomography (PET) using [18F]fluoride is commonly applied for non-invasive quantification of bone metabolism. Limitations in detection sensitivity/specificity and quantification methodology of [18F]fluoride-PET hamper precise characterization of bone lesions. The aims of this study were to understand the technical and methodological limitations of bone metabolism investigation by PET and to discover a suitable receptor-ligand system for skeletal imaging – for improving the accuracy of bone lesion evaluation thus giving invaluable information for treatment planning and management.
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