MicroRNA signatures predict early major coronary events in middle-aged men and women

摘要

MicroRNAs share many of the essential features of a good circulating biomarker1 , but despite promising data on their role in risk prediction for major adverse coronary events (MACEs)2,3 , more investigation is needed for translation to the clinic. Thus, we have sought to identify circulating microRNA signatures able to predict MACEs, defined as myocardial infarction (MI), angina, or sudden cardiac death (Supplementary Fig. I).