Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction

摘要

Chronic postischemic remodeling is a major cause of mortality and morbidity worldwide. While ventricular remodeling involves complex mechanisms, energetic deficit, dysregulation of Ca2 handling and oxidative stress are important hallmarks of the failing cardiomyocyte1 . Mitochondria are at the centre of these processes as they are the main source of ATP and reactive oxygen species (ROS) and their function is critically controlled by Ca2 2 .