Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil

Matilde del Carmen Contreras Mejía; Maísa Porto Dos Santos; George Allan Villarouco da Silva; Isabella da Motta Passos; Felipe Gomes Naveca; Maria da Gra?a Souza Cunha; Milton Ozório Moraes; Lucia de Paula

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Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil

机译：在巴西亚马逊州麻风病人的麻风分枝杆菌菌株中对利福平的原发耐药性鉴定

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The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.

机译：这项研究的目的是确定巴西亚马逊州麻风病患者的 folp1 ， gyrA 和 rpoB 基因的多态性。在197例未治疗或复发患者的裂口皮肤涂片样本中，我们发现3例原发性对利福平耐药，1例确诊为多药耐药。 展开▼

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《Journal of Clinical Microbiology》 |2014年第12期|共2页

作者
Matilde del Carmen Contreras Mejía; Maísa Porto Dos Santos; George Allan Villarouco da Silva; Isabella da Motta Passos; Felipe Gomes Naveca; Maria da Gra?a Souza Cunha; Milton Ozório Moraes; Lucia de Paula;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Emergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India [J] . Lavania M., Nigam A., Turankar R. P., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2015,第12期

机译：印度麻风病人麻风分枝杆菌菌株对利福平的主要耐药性出现

2. Emergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India [J] . Lavania M., Nigam A., Turankar R. P., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2015,第12期

机译：印度麻风病人麻风分枝杆菌菌株对利福平的主要耐药性出现

3. Drug and Multidrug Resistance among Mycobacterium leprae Isolates from Brazilian Relapsed Leprosy Patients [J] . Adalgiza da Silva Rocha, Maria das Gra?as Cunha, Lucia Martins Diniz, Journal of Clinical Microbiology . 2012,第6期

机译：巴西复发性麻风病患者麻风分枝杆菌分离株的耐药性和多药耐药性

4. Inferences on Mycobacterium Leprae Host Immune Response Escape and Antibiotic Resistance Using Genomic Data and GenomeFastScreen [C] . Hugo López-Fernández, Cristina P. Vieira, Florentino Fdez-Riverola, International Conference on Practical Applications of Computational Biology Bioinformatics . 2021

机译：使用基因组数据和基因组屏幕宿主宿主宿主免疫反应逃逸和抗生素抗性的推论

5. Drug Resistance in Mycobacterium tuberculosis: An Investigation of Drug Transporter P-Glycoprotein and an Evaluation of Improved Diagnosis of Drug Resistant Tuberculosis in Cameroonian Pulmonary Tuberculosis Patients [D] . Abanda, Ngu Njei 2017

机译：结核分枝杆菌的耐药性：转运蛋白P-糖蛋白的调查和喀麦隆肺结核患者耐药性结核病改善诊断的评估

6. Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State Brazil [O] . Matilde del Carmen Contreras Mejía, Maísa Porto Dos Santos, George Allan Villarouco da Silva, 2014

机译：在巴西亚马逊州麻风病人的麻风分枝杆菌菌株中对利福平的原发耐药性鉴定

7. Emergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India [O] . Lavania M., Nigam A., Turankar R.P., 2015

机译：印度麻风病患者麻风分枝杆菌菌株对利福平的主要耐药性出现

1. 麻风病人尿和血清中抗麻风分枝杆菌35KD决定簇抗体的检测 [J] . Pati.S ,孟梅白 . 地方病译丛 . 1992,第001期

2. 少菌型麻风病人对利福平和氨苯砜的原发性耐药 [J] . 陈均銮 . 中国麻风皮肤病杂志 . 1989,第002期

3. 结核菌株对利福喷汀和利福平的耐药性研究 [J] . 匡铁素 ,宋萍 . 中国抗生素杂志 . 1997,第004期

4. 农业部、国家质检总局联合发布公告禁止从巴西亚马逊州进口禽类及其产品 [J] . . 水禽世界 . 2006,第005期

5. 结核分枝杆菌利福平耐药菌株补偿性突变的系统性鉴定 [J] . 左天宇 ,柳清云 ,甘明宇 . 中华结核和呼吸杂志 . 2018,第003期

6. 基因芯片技术在分枝杆菌菌种鉴定和结核耐药性检测中的诊断价值 [C] . 李丹 ,杜德兵 ,向启云 . 2017中国医疗保健国际交流促进会结核病分会基础和临床学组第二届学术年会、全国结核病诊疗与防控暨第二届中西医结合治疗基础与临床新进展研讨会 . 2017

7. Xpert MTB/RIF检测骨关节结核病灶中结核分枝杆菌及利福平耐药性的研究 [A] . 李祯 . 2016

1. 一种鉴定毛栓孔菌S0301中同核体菌株的方法 [P] . 中国专利： CN108486269B . 2021.08.20

2. 用于乳粉中双歧杆菌菌株鉴定的SNP位点组合 [P] . 中国专利： CN107604082B . 2018.09.25

3. Probe for Detection of Rifampin Resistance of Mycobacterium leprae and the kit [P] . 外国专利： KR101001368B1 . 2010-12-14

机译：麻风分枝杆菌对利福平耐药的检测探针和试剂盒

4. PROBE FOR DETECTION OF RIFAMPIN RESISTANCE OF MYCOBACTERIUM LEPRAE AND THE KIT [P] . 外国专利： KR20090121610A . 2009-11-26

机译：检测麻风分枝杆菌及其工具的利福平耐药性的探针

5. IMPROVED QUANTAMATRIX ASSAY PLATFORM-BASED, DIAGNOSTIC METHOD CAPABLE OF SIMULTANEOUSLY IDENTIFYING DETECTION OF MYCOBACTERIUM TUBERCULOSIS AND RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO RIFAMPIN, ISONIAZID, ETHAMBUTOL, QUINOLONE, SECOND LINE INJECTABLE DRUGS SUCH AS AMIKACIN, KANAMYCIN, AND CAPEOMYCIN, AND STREPTOMYCIN DRUGS, AND KIT THEREFOR [P] . 外国专利： WO2019225959A1 . 2019-11-28

机译：基于改进的量子矩阵分析平台的诊断方法，能够同时鉴定结核分枝杆菌的结核分枝杆菌，以及对结核分枝杆菌对利福平，异烟肼，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇，肌醇和肌醇那个

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Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil

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