Rapid Differentiation of Haemophilus influenzae and Haemophilus haemolyticus by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry with ClinProTools Mass Spectrum Analysis

摘要

Haemophilus influenzae and Haemophilus haemolyticus are the most prevalent Haemophilus species colonizing the human pharyngeal cavity (1). H. influenzae causes various respiratory tract diseases, such as sinusitis, otitis media, and pneumonia, as well as infective exacerbations of chronic obstructive pulmonary disease and bronchiectasis (2). In contrast, H. haemolyticus colonizes healthy subjects at moderate prevalence and rarely causes infections in the respiratory tract (3–5).