Identification of Acute HIV-1 Infection by Hologic Aptima HIV-1 RNA Qualitative Assay

摘要

An understanding of host-virus interactions in early acute HIV-1 infection (AHI) is critical for the design of effective intervention strategies to reduce rates of HIV-1 transmission and improve long-term outcomes (1–4). Implementation of intervention strategies early in infection, at the time of highest viral burden in blood, semen, and other fluids, can significantly reduce epidemic spread of the infection (5–9). Moreover, initiation of antiviral treatment early in the course of infection may be more effective in disrupting the establishment of stable viral reservoirs and may slow the progression of infection, with possible implications for eventual viral cure (10–12).