Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma

Hart B. Moss; Sai Chavala; Emil Say; Melissa B. Miller

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Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma

机译：更昔洛韦耐药性巨细胞病毒（CMV）视网膜炎患者血浆中的野生型巨细胞病毒。

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A patient with systemic cytomegalovirus (CMV), including chorioretinitis, received localized and systemic ganciclovir, systemic cidofovir analog, and localized foscarnet. Mutations conferring ganciclovir and cidofovir resistance were detected in CMV from the aqueous fluid but not in CMV from plasma. Quantifying CMV from aqueous fluid was valuable for monitoring the clinical response and predicting resistance.

机译：患有全身性巨细胞病毒（CMV）（包括脉络膜视网膜炎）的患者接受了局部和全身更昔洛韦，全身西多福韦类似物和局部膦甲酸治疗。在水性液体的CMV中检测到更昔洛韦和西多福韦耐药的突变，而血浆中的CMV未检测到。从水性液体中定量CMV对于监测临床反应和预测耐药性非常有价值。

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《Journal of Clinical Microbiology》 |2012年第5期|共4页
作者
Hart B. Moss; Sai Chavala; Emil Say; Melissa B. Miller;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis after stem cell transplantation: effective monitoring of CMV infection by quantitative analysis of CMV mRNA. [J] . Ohta H, Matsuda Y, Tokimasa S, Bone marrow transplantation . 2001,第11期

机译：Foscarnet治疗干细胞移植后更昔洛韦耐药的巨细胞病毒性视网膜炎：通过定量分析CMV mRNA有效监测CMV感染。
2. Cytomegalovirus (CMV) blood DNA load, CMV retinitis progression, and occurrence of resistant CMV in patients with CMV retinitis. [J] . Jabs DA, Martin BK, Forman MS, The Journal of Infectious Diseases . 2005,第4期

机译：巨细胞病毒（CMV）血液DNA负荷，CMV视网膜炎进展以及CMV视网膜炎患者中耐药性CMV的发生。
3. Incidence of cytomegalovirus (CMV) retinitis in fellow eyes of HIV-infected patients with unilateral CMV retinitis treated with intravitreal ganciclovir injections [J] . Alsberge Joseph B., Ausayakhun Somsanguan, Lirawison Choeng, Investigative ophthalmology & visual science . 2016,第12期

机译：用玻璃体内incanciclovir注射治疗的艾滋病毒感染患者同胞患者患有单侧CMV视网膜炎的患者的细胞瘤病毒（CMV）视网膜炎的发病率
4. Microfluidic device for rapid detection of cytomegalovirus (CMV) by sequence-specific hybridization of PCR-amplified CMV-DNA [C] . Briones, M.P., Yamashita, . 2006

机译：通过PCR扩增的CMV-DNA的序列特异性杂交快速检测巨细胞病毒（CMV）的微流体装置
5. Molecular characterization of a gene from a novel rodent cytomegalovirus (PCMV) and the potential use of PCMV as an expression vector for hantavirus glycoproteins. [D] . van Geelen, Albertus Gertrudis Maria. 1999

机译：新型啮齿动物巨细胞病毒（PCMV）基因的分子表征以及PCMV作为汉坦病毒糖蛋白表达载体的潜在用途。
6. Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma [O] . Hart B. Moss, Sai Chavala, Emil Say, 2012

机译：抗更昔洛韦的巨细胞病毒（CMV）视网膜炎患者血浆中的野生型CMV。
7. Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis after stem cell transplantation: effective monitoring of CMV infection by quantitative analysis of CMV mRNA [O] . H Ohta, Y Matsuda, S Tokimasa, 2001

机译：干细胞移植后耐血清洛昔洛尿嘧啶病毒性视网膜病毒治疗：CMV mRNA定量分析有效监测CMV感染
8. Database Documentation for Mortality in Patients with Acquired Immunodeficiency Treated with Either Foscarnet or Ganciclovir for Cytomegalovirus Retinitis: The Foscarnet-Ganciclovir CMV Retinitits Trail (FGCRT). [R] . 2002

机译：用膦甲酸或更昔洛韦治疗巨细胞病毒视网膜炎获得性免疫缺陷患者死亡率的数据库文件：Foscarnet-Ganciclovir CmV Retinitits Trail（FGCRT）。

Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma

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