Colistin and Polymyxin B Susceptibility Testing for Carbapenem-Resistant and mcr-Positive Enterobacteriaceae: Comparison of Sensititre, MicroScan, Vitek 2, and Etest with Broth Microdilution

摘要

Multidrug-resistant organisms (MDROs) represent a progressive burden on health care systems globally. Carbapenem-resistant Enterobacteriaceae (CRE) are now reported worldwide. CRE infections are difficult to treat, and there are limited options available. The polymyxins (colistin and polymyxin B) are antibiotics which are used for treating infections with CRE. Polymyxins initially fell out of favor among clinicians due to concerns over high rates of nephrotoxicity and neurotoxicity (1). In recent years, the use of polymyxins has been on the rise, with increasing rates of CRE infection. Combination therapy is often used for additive or synergistic antimicrobial activity (2, 3).