Carbapenemase Detection among Carbapenem-Resistant Glucose-Nonfermenting Gram-Negative Bacilli

摘要

While the critical threat of carbapenemase-producing Enterobacteriaceae (CPE) has become increasingly recognized over recent years (1, 2), there remains an underappreciation for the hazards posed by carbapenemase-producing glucose-nonfermenting Gram-negative bacilli (CPNFs). Increasing reports of CPNFs, dominated by Pseudomonas aeruginosa and Acinetobacter baumannii, are worrisome as many of these carbapenemase genes have demonstrated mobility across Gram-negative species, regardless of an organism's ability to ferment glucose (3). Lack of recognition and detection of CPNFs may further perpetuate the problem of carbapenem resistance among all Gram-negative organisms.