Identification of the Hypervirulent Lineages of Neisseria meningitidis, the ST-8 and ST-11 Complexes, by Using Monoclonal Antibodies Specific to NmeDI

Heike Claus; Hanne Weinand; Matthias Frosch; Ulrich Vogel

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Identification of the Hypervirulent Lineages of Neisseria meningitidis, the ST-8 and ST-11 Complexes, by Using Monoclonal Antibodies Specific to NmeDI

机译：通过使用NmeDI特异的单克隆抗体鉴定脑膜炎奈瑟氏球菌，ST-8和ST-11复合物的高毒力谱系

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Most cases of serogroup C meningococcal disease are caused by the clonal lineages ST-8 and ST-11. The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification.

机译：血清C型脑膜炎球菌大多数病例是由ST-8和ST-11克隆系引起的。编码假定的限制性修饰系统 Nme DI的基因对这些谱系具有特异性。我们在这里报告针对 Nme DI核酸内切酶的单克隆抗体，作为其快速，专业鉴定的工具。 展开▼

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《Journal of Clinical Microbiology》 |2003年第8期|共4页

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Heike Claus; Hanne Weinand; Matthias Frosch; Ulrich Vogel;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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专利

1. High prevalence of Neisseria meningitidis hypervirulent lineages and emergence of W135:P1.5,2:ST-11 clone in Southern Brazil. [J] . Weidlich L, Baethgen LF, Mayer LW, Journal of Infection . 2008,第4期

机译：巴西南部脑膜炎奈瑟氏菌高毒谱系的高流行和W135：P1.5,2：ST-11克隆的出现。

2. Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis [J] . Mustapha M. Mustapha, Jane W. Marsh, Mary G. Krauland, EBioMedicine . 2015,第10期

机译：W，ST-11脑膜炎奈瑟氏球菌高毒血清群的基因组流行病学

3. Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis [J] . Mustapha M. Mustapha, Jane W. Marsh, Mary G. Krauland, EBioMedicine . 2015,第10期

机译：W，ST-11脑膜炎奈瑟氏球菌高毒血清群的基因组流行病学

4. A STRUCTURAL EXPLANATION OF THE IMPORTANCE OF ACETYLATION IN NEISSERIA MENINGITIDIS SEROGROUP. A CAPSULAR POLYSACCHARIDES TO RAISE FUNCTIONAL ANTIBODIES [C] . Pedro Henriques, Barbara Brogioni, Alessia Biolchi International Carbohydrate Symposium . 2018

机译：乙酰化在脑膜炎奈瑟氏菌的重要性的结构解释。胶囊多糖，用于提高功能抗体

5. Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis. [D] . Ingrey, Keely. 2010

机译：脑膜炎奈瑟氏球菌中假定的血红素ABC转运蛋白的鉴定和分子表征。

6. Identification of the Hypervirulent Lineages of Neisseria meningitidis the ST-8 and ST-11 Complexes by Using Monoclonal Antibodies Specific to NmeDI [O] . Heike Claus, Hanne Weinand, Matthias Frosch, 2003

机译：通过使用NmeDI特异的单克隆抗体鉴定脑膜炎奈瑟氏球菌ST-8和ST-11复合物的高毒力谱系

7. Identification of the Hypervirulent Lineages of Neisseria meningitidis, the ST-8 and ST-11 Complexes, by Using Monoclonal Antibodies Specific to NmeDI [O] . Claus, Heike, Weinand, Hanne, Frosch, Matthias, 2003

机译：通过使用NmeDI特异的单克隆抗体鉴定脑膜炎奈瑟氏球菌，ST-8和ST-11复合物的高毒力谱系

8. Monoclonal Antibodies to Serotype 2 and Serotype 15 Outer Membrane Proteins of Neisseria meningitidis and Their Use in Serotyping. [R] . Zollinger, W. D., Moran, E. E., Connelly, H., 1984

机译：脑膜炎奈瑟菌血清型2和血清型15外膜蛋白的单克隆抗体及其在血清分型中的应用。

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2. 2013-2015年北京市门头沟区健康人群脑膜炎奈瑟氏球菌带菌率分析 [J] . 刘海涛 ,庄国良 ,王志越 . 首都公共卫生 . 2016,第002期

3. 脑膜炎奈瑟氏球菌感染中毒症1例 [J] . 陶思 ,汤多壮 ,汤屹 . 内科急危重症杂志 . 2008,第003期

4. A群奈瑟氏脑膜炎球菌荚膜多糖-破伤风类毒素结合疫苗的制备及其免疫原性研究 [J] . 刘方蕾 ,吴兵 ,杜琳 . 微生物学免疫学进展 . 2005,第002期

5. C群奈瑟氏脑膜炎球菌荚膜多糖-TT结合疫苗的制备及其在小鼠体内免疫原性的研究 [J] . 吴兵 ,刘方蕾 ,崔萱林 . 微生物学免疫学进展 . 2005,第003期

6. 脑膜炎奈瑟球菌外膜蛋白NMB0315的晶体结构研究 [A] . 王向宇 . 2014

1. 含重组菌毛蛋白的抗淋病奈瑟氏球茵或脑膜炎奈瑟氏球菌的疫苗 [P] . 中国专利： CN1245512C . 2006.03.15

2. 含重组菌毛蛋白的抗淋病奈瑟氏球茵或脑膜炎奈瑟氏球菌的疫苗 [P] . 中国专利： CN1298446A . 2001-06-06

3. pencicillin-binding protein, nucleic acid, antibody or antibody fragment, medicament, pharmaceutical composition, uses of at least one penicillin-binding protein or fragment or variant or fragment thereof, of at least one nucleic acid and of at least one antibody or antibody fragment, in vitro antibody detection methods directed against neisseria meningitidis infection from a penicillin-binding protein, nucleic acid, antibody or an antibody fragment, pharmaceutical composition of at least one penicillin-binding protein or fragment or variant or variant thereof, of at least one nucleic acid and at least one antibody directed against neisseria meningitidis infection from a biological sample of a mammal and in vitro diagnosis of neisseria miningitidis infection from a biological sample from a mammal and monoclonal antibody [P] . 外国专利： BRPI0610802A2 . 2016-11-16

机译：青霉素结合蛋白，核酸，抗体或抗体片段，药物，药物组合物，至少一种青霉素结合蛋白或其片段或变异体或片段，至少一种核酸和至少一种抗体或抗体片段的用途，针对脑膜炎奈瑟菌的青霉素结合蛋白，核酸，抗体或抗体片段感染的体外抗体检测方法，至少一种青霉素结合蛋白或其片段或变异体或变异体，至少一种核酸的药物组合物酸和至少一种针对哺乳动物生物样品中脑膜炎奈瑟氏菌感染的抗体以及来自哺乳动物生物样品中的矿业性奈瑟氏球菌感染的体外诊断和单克隆抗体

4. Proteinase K resistant surface protein of Neisseria meningitidis and its use in treating Neisseria infections with a Neisseria-derived monoclonal antibody. [P] . 外国专利： NZ303118A . 2000-07-28

机译：脑膜炎奈瑟氏球菌的蛋白酶K抗性表面蛋白及其在源自奈瑟氏菌的单克隆抗体治疗奈瑟氏菌感染中的应用。

5. Monoclonal Antibodies APPLICATION FOR IDENTIFICATION OR YAMAGATSKOY Victorian evolutionary lineages of influenza virus type B. STRAIN 4N7 hybrids to produce monoclonal antibodies for certain viruses influenza YAMAGATSKOY branches. STRAIN hybrids / 4H1 For preparation of monoclonal antibodies for certain viruses Influenza Victorian BRANCH [P] . 外国专利： RU2011127014A . 2013-01-10

机译：单克隆抗体鉴定或YAMAGATSKOY的应用B型流感病毒的维多利亚州进化谱系。应变4N7杂种可为某些病毒YAMAGATSKOY分支产生单克隆抗体。 STRAIN hybrids / 4H1用于制备某些病毒的单克隆抗体维多利亚维多利亚分公司

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Identification of the Hypervirulent Lineages of Neisseria meningitidis, the ST-8 and ST-11 Complexes, by Using Monoclonal Antibodies Specific to NmeDI

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