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首页> 外文期刊>Journal of Clinical Microbiology >Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark
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Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark

机译:丹麦对症状性诺如病毒(GGII.4)感染的宿主遗传抗性

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A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
机译: FUT2 基因的第428位和第571位核苷酸处对涉及丹麦5次诺如病毒暴发的61位个体进行了基因分型,确定了分泌者的状态,即分泌物中和粘膜上是否存在ABH抗原。发现分泌型表型与症状性疾病之间有很强的相关性( P = 0.003),扩展了先前的知识并确认了 FUT2 基因中的无意义突变可提供针对症状性诺如病毒的保护作用( GGII.4)感染。

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