Analysis of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) isolates in Hong Kong by use of a combination of antibiogram typing, serotyping, multilocus sequence typing, and pulsed-field gel electrophoresis indicated that the dissemination of PNSP was the result of the spread of international clones: variants of the Spain23F-1 or Spain6B-2 clones were the predominant PNSP isolates from 1994 to 1997 and remained so, but Taiwan19F-14 and Taiwan serotype 6B clones were disseminated in Hong Kong in 1999 and 2000. Concomitant changes in antibiotic susceptibility profiles, with the rate of susceptibility to chloramphenicol rising from 10% in the period from 1994 to 1997 to 31% (P < 0.001) in 1999 and 2000, were noted to accompany the shift of clones.
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机译：对青霉素不敏感的肺炎链球菌（PNSP）分离株进行了抗菌谱分型，血清分型，多位点序列分型和脉冲场凝胶电泳分析，结果表明PNSP的传播是国际克隆传播的结果：西班牙 23F -1或西班牙 6B -2克隆的变种是1994年至1997年的主要PNSP分离株，但仍然如此，但台湾1999年和2000年在香港传播了 19F -14和台湾6B血清型克隆。抗生素敏感性分布的变化，1994年至1997年期间对氯霉素的敏感性从10％上升。到1999年和2000年，有31％（ P <0.001）伴随着克隆的转移。
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