Molecular Epidemiology of Haemophilus influenzae Type b Isolated from Children with Clinical Cases of Conjugate Vaccine Failures

摘要

We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti-H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.