Searching for Darwinian selection in natural populations has been the focus of a multitude of studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 (http://hsb.upf.edu) as a resource for signatures of recent natural selection in modern humans. We have implemented and applied a large number of neutrality tests as well as summary statistics informative for the action of selection such as Tajima's D, CLR, Fay and Wu's H, Fu and Li's F* and D*, XPEHH, ΔiHH, iHS, FST, ΔDAF and XPCLR among others to low coverage sequencing data from the 1000 genomes project (Phase 1; release April 2012). We have implemented a publicly available genome-wide browser to communicate the results from three different populations of West African, Northern European and East Asian ancestry (YRI, CEU, CHB). Information is provided in UCSC-style format to facilitate the integration with the rich UCSC browser tracks and an access page is provided with instructions and for convenient visualization. We believe that this expandable resource will facilitate the interpretation of signals of selection on different temporal, geographical and genomic scales.
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机译：在过去的几十年中，在自然种群中寻找达尔文选择一直是众多研究的重点。在这里，我们介绍了1000个基因组选择浏览器1.0（http://hsb.upf.edu），作为现代人类最近自然选择的签名资源。我们已实施并应用了大量中立性测试以及摘要统计信息，这些信息可为选择提供帮助，例如田岛D，CLR，Fay和Wu的H，Fu和Li的F *和D *，XPEHH，ΔiHH，iHS，F ST ，ΔDAF和XPCLR等来自1000个基因组计划的低覆盖度测序数据（第1阶段; 2012年4月发布）。我们已经实现了可公开访问的全基因组浏览器，以交流来自西非，北欧和东亚血统（YRI，CEU，CHB）三个不同种群的结果。信息以UCSC样式格式提供，以促进与丰富的UCSC浏览器轨道的集成，并且提供了带有说明的访问页面以及方便的可视化。我们认为，这种可扩展的资源将有助于在不同的时间，地理和基因组尺度上解释选择信号。
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