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首页> 外文期刊>Journal of Medical Case Reports >Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature
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Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature

机译:表现为黄疸的纯睾丸绒毛膜癌1例并文献复习

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Introduction Testicular cancer is the most common malignancy in men 15- to 35-years-old. The North American standard classification divides testicular cancers into germ cell tumors and non-germ cell tumors. The lymphatic spread of germ cell tumors usually involves the retroperitoneal lymph nodes. However, this spread to the retroperitoneum rarely involves the hepatic hilum. We describe an unusual case of metastatic choriocarcinoma of the testis that was clinically mimicked by a cholestatic jaundice. This is an unusual presentation of testicular cancer and, to the best of our knowledge, the first report of this kind in the literature. Case presentation A 28-year-old Moroccan man presented with a four-week history of progressive obstructive jaundice, and weight loss to our emergency department. Abdominal ultrasound showed a dilatation of the biliary ducts due to pathologically enlarged lymph nodes of the hepatic hilum. A complete clinical and radiologic assessment to discover the primary tumor was negative except for pulmonary metastasis. In the laboratory findings at admission there were signs of cholestasis with an abnormal increase in the rate of testicular tumor markers (serum beta-human chorionic gonadotropin level was 11,000IU/ml), which subsequently led to the suspicion of a testicular tumor. Further evaluation included testicular palpation and ultrasound which revealed a testicular nodule. The patient underwent an inguinal orchidectomy of the right testis and histopathological examination confirmed a pure choriocarcinoma. The prognosis was poor due to lymph node involvement at the hepatic hilum. He died one month later, despite general chemotherapy. Conclusions The clinical presentation of the disease and the rarity of this entity are two remarkable characteristics described in this case report which are rarely reported in literature.
机译:简介睾丸癌是15至35岁男性中最常见的恶性肿瘤。北美标准分类将睾丸癌分为生殖细胞肿瘤和非生殖细胞肿瘤。生殖细胞肿瘤的淋巴扩散通常涉及腹膜后淋巴结。但是,这种扩散到腹膜后的情况很少涉及肝门。我们描述了由胆汁淤积性黄疸在临床上模仿的睾丸转移性绒毛膜癌的罕见病例。这是睾丸癌的不寻常表现,据我们所知,这是文献中的首次此类报道。病例介绍一名28岁的摩洛哥男子向我们的急诊科介绍了为期4周的进行性阻塞性黄疸和体重减轻的病史。腹部超声显示,由于肝门的淋巴结在病理上扩大,导致胆管扩张。除肺转移外,发现原发肿瘤的完整临床和放射学评估均为阴性。在入院时的实验室检查结果中发现胆汁淤积的迹象,睾丸肿瘤标志物的比率异常升高(血清β-人绒毛膜促性腺激素水平为11,000IU / ml),随后导致怀疑睾丸肿瘤。进一步的评估包括睾丸触诊和超声检查发现睾丸结节。该患者接受了右侧睾丸的腹股沟睾丸切除术,组织病理学检查证实为纯绒毛膜癌。由于肝门淋巴结受累,预后较差。尽管进行了常规化疗,但他在一个月后死亡。结论该疾病的临床表现和该实体的稀有性是本病例报告中描述的两个显着特征,在文献中很少报道。

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