One needs to think outside of the box, as one of us (Ronald B Luftig) learned from many years as a mathematician, and a biophysicist. In this short Review, the need to focus on producing high levels of neutralizing antibodies (NAbs) to incoming and conformationally altered virus after it has bound to CD4+ cells is essential. Increasing the number of gp120 molecules on the surface of L-2 particles, could allow for an enhanced number of NAbs. The attempt at increasing CD8+ T cell responses in recent vaccine trials has not worked perhaps because it may have allowed HIV to enter into remote sanctuaries. Our approach focuses on increasing NAbs, before high levels of CD8+ T cells are produced.
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机译：我们其中一位（Ronald B Luftig）作为数学家和生物物理学家已经学习了很多年，这需要我们自己思考。在这篇简短的综述中，必须重点关注在与CD4 +细胞结合后针对传入的和构象改变的病毒产生高水平的中和抗体（NAb）。增加L-2颗粒表面上gp120分子的数量，可以增加NAb的数量。在最近的疫苗试验中尝试增加CD8 + T细胞反应的尝试并未奏效，可能是因为它可能使HIV进入了偏远的庇护所。我们的方法侧重于在产生高水平的CD8 + T细胞之前增加NAb。
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