The effect on immune function and inflammatory factors of adjuvant antibiotic therapy through Xuebijing combined with thymopentin in elderly patients with severe pneumonian

摘要

Objective: To investigate the effect on immune function and inflammatory factors of adjuvantantibiotic therapy through Xuebijing combined with thymopentin in elderly patients withsevere pneumonia. Methods: Divided 100 cases of elderly patients with severe pneumoniainto the observation group and the treatment group according to odevity of serial number. Fiftypatients in each group. Gave control group severe pneumonia conventional treatment, such asmechanical ventilation, antifebrile, removing phlegm and anti-infection, and gave Xuebijingby intravenous drop simultaneously; observation group was given Xuebijing combined withthymopentin by intravenous drop on the base of conventional treatment. Then compared theT lymphocyte subpopulation and serum inflammatory factors level including CRP, IL-6, IL-1and TNF-α of two groups before treatment and 7 d, 14 d of treatment respectively. Result:(1) There was significant difference in the level of CD3+, CD4+, CD8+, CD4+/CD8+ in thistwo groups at different time points, and that the level of CD3+, CD4+, CD4+/CD8+: T2＞T1＞T0, CD8+ level: T2＜T1＜T0; The increasing range of CD3+, CD4+, CD4+/CD8+level and thedecreasing range of CD8+ in the observation group were larger than that in the control group,there was statistical significant difference. (2) The level of serum inflammatory factors CRP,IL-6, IL-1, TNF-α in two groups at different time points were statistical significant difference,all the CRP, IL-6, IL-1 and TNF-α level were T2＜T1＜T0, presenting a downward trend;The descending range of serum CRP, IL-6, IL-1, TNF-α level in the observation was largercompared with the control group, there was significant difference. Conclusion: The adjuvantantibiotic therapy through Xuebijing combined with thymopentin in elderly patients withsevere pneumonia could improve the immune function and lower the inflammatory factorslevel.