In vitro evaluation of antimicrobial and cytotoxic effects of Caper (Capparisspinosa)

摘要

Nature has been the source of medicinal agents for thousands of years, and an impressive number ofmodern drugs have been isolated from natural sources, many based on their use in traditional medicine. Hence the present study was aimed toin vitro evaluation of the antimicrobial and cytotoxic effects of acetone, ethanol, ethyl acetate, petroleum ether, methanol and boiled water extracts of Capparisspinosa. All crude extracts showed significant activity as antimicrobial andcytotoxic effect. Ethyl acetate extract exhibitedmaximum significant antimicrobial and cytotoxic activity. Klebsiella pneumonia and Enterococcus faecalis was the most sensitive organism with inhibition zone 36 and 29 mm respectively whereas Rhizopusstolonifer and Fusariummoniliforme was the most sensitive fungi with inhibition zone 25 and 21 mm respectively. Cytotoxicity evaluation of C. spinosaon HeLa cell line viability indicated that ethanol and methanol extracts showed very strong cytotoxic activity with cell line viability 10 % and 23.33% respectively. Cytotoxicity evaluation of C. spinosa on MCF- 7 cell line viability indicated that ethanol extract showed strong cytotoxic activity with cell line viability 37.31 %. Caper extracts are potential sources of novelantimicrobial and antitumor compounds. Also, it is an important species in our natural surrounding and economy because of its high nutrition flowersand buds,high adaptation capability and medicinal efficiency. All these features emphasis the fact that C.spinosacan be a promisingmedication in recent century.