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In vitro evaluation of antimicrobial and cytotoxic effects of Caper (Capparisspinosa)

机译:Caper(Capparisspinosa)的抗微生物和细胞毒性作用的体外评估

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Nature has been the source of medicinal agents for thousands of years, and an impressive number ofmodern drugs have been isolated from natural sources, many based on their use in traditional medicine. Hence the present study was aimed toin vitro evaluation of the antimicrobial and cytotoxic effects of acetone, ethanol, ethyl acetate, petroleum ether, methanol and boiled water extracts of Capparisspinosa. All crude extracts showed significant activity as antimicrobial andcytotoxic effect. Ethyl acetate extract exhibitedmaximum significant antimicrobial and cytotoxic activity. Klebsiella pneumonia and Enterococcus faecalis was the most sensitive organism with inhibition zone 36 and 29 mm respectively whereas Rhizopusstolonifer and Fusariummoniliforme was the most sensitive fungi with inhibition zone 25 and 21 mm respectively. Cytotoxicity evaluation of C. spinosaon HeLa cell line viability indicated that ethanol and methanol extracts showed very strong cytotoxic activity with cell line viability 10 % and 23.33% respectively. Cytotoxicity evaluation of C. spinosa on MCF- 7 cell line viability indicated that ethanol extract showed strong cytotoxic activity with cell line viability 37.31 %. Caper extracts are potential sources of novelantimicrobial and antitumor compounds. Also, it is an important species in our natural surrounding and economy because of its high nutrition flowersand buds,high adaptation capability and medicinal efficiency. All these features emphasis the fact that C.spinosacan be a promisingmedication in recent century.
机译:数千年来,大自然一直是药物的来源,并且已经从自然资源中分离出了令人印象深刻的现代药物,其中许多是基于传统药物的用途。因此,本研究旨在体外评价辣椒,丙酮,乙醇,乙酸乙酯,石油醚,甲醇和白开水提取物的抗微生物和细胞毒性作用。所有粗提取物均表现出显着的抗微生物和细胞毒性作用。乙酸乙酯提取物表现出最大的显着抗微生物和细胞毒性活性。肺炎克雷伯菌和粪肠球菌是最敏感的生物,抑制区分别为36和29 mm,而根瘤菌和镰孢镰刀菌是最敏感的真菌,抑制区分别为25和21 mm。 C. spinosaon HeLa细胞系活力的细胞毒性评估表明,乙醇和甲醇提取物显示出非常强的细胞毒性活性,细胞系活力分别为10%和23.33%。棘孢梭菌对MCF-7细胞系活力的细胞毒性评价表明,乙醇提取物显示出强的细胞毒性活性,细胞系活力为37.31%。刺山柑提取物是新型抗微生物和抗肿瘤化合物的潜在来源。同时,由于其高营养的花和芽,高适应能力和高药效,它是我们自然环境和经济中的重要物种。所有这些特征都强调了一个事实,即梭状芽胞杆菌在近世纪是有前途的药物。

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