Neurotoxic Effect of Mercury

摘要

Mercury exposure remain a problem since it is ubiquitous and human exposure is inevitable. Its potent neurotoxic effect is associated with permanent disability and death. Microtubulin and microglia are vulnerable to neurotoxict substance .The alteration of their number in respond to toxic agent will be destructif and deadly to central nervous system.Therefore the present study investigates the dose relationship between mercury exposure and their count in brain. Male rats (Rattus Novergicus) were used to determine the neurotoxic effect of methylmercurychloride on their brain using microglia and microtubulin as parameter. Varying dose of MeHgCl3 from 0,2 mg/BW to 0,8 mg/BW had been administered via nasogastric tube for 21 days, then the brains were removed and microglia & microtubulin count were scored. Microtubulin count were 54.3; 48.1; 39.25; 25.85; 15.65 (CI 95%) respectively. Microglia count were 9,75; 23.95; 32.5;44.4;58.35 (CI 95%) respectively. It could be conclude that methylmercury chloride exposure will decrease microtubulin count in an inverse dose relationship whereas microglia count will increase in dose dependent manner.