Effects of inorganic metal salts on chromosome length in human lymphocytes

摘要

Spindle inhibitors (colchicine, parafluorophenylalanine) have been demonstrated to reduce the average chromosome length. In this report chromosome length measurements were used for quantitative measurement of the effects of Cd++ Hg++ AsO2- SeO3- on the spindle. All four metal compounds significantly reduced the average chromosome length. Induction of metallothionein seemed to modify the spindle-inhibiting effects of Cd++ Hg++.