Does sex hormone-binding globulin cause insulin resistance during pubertal growth?

Shenglong Le; Leiting Xu; Moritz Schumann; Na Wu; Timo T?rm?kangas; Markku Alén; Sulin Cheng; Petri Wiklund

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Does sex hormone-binding globulin cause insulin resistance during pubertal growth?

机译：性激素结合球蛋白会在青春期生长期间引起胰岛素抵抗吗？

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BackgroundThe directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. The aim of this study was to investigate bidirectional associations between SHBG and insulin resistance (HOMA-IR) and adiposity from childhood to early adulthood.

机译：背景青春期期间血清性激素结合球蛋白（SHBG），肥胖和胰岛素抵抗之间的方向性影响尚不清楚。这项研究的目的是调查从儿童期到成年早期SHBG与胰岛素抵抗（HOMA-IR）和肥胖之间的双向关联。

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《Endocrine Connections》 |2019年第5期|共8页
作者
Shenglong Le; Leiting Xu; Moritz Schumann; Na Wu; Timo T?rm?kangas; Markku Alén; Sulin Cheng; Petri Wiklund;
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中图分类内科学;
关键词
sex hormone-binding globulininsulin resistanceadipositypubertymenarche;

机译：性激素结合球蛋白胰岛素抵抗肥胖青春期初潮;

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1. Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells. [J] . Kalme T, Koistinen H, Loukovaara M, The Journal of Steroid Biochemistry and Molecular Biology . 2003,第2期

机译：胰岛素和胰岛素样生长因子对人肝癌细胞中胰岛素样生长因子结合蛋白-1（IGFBP-1）和性激素结合球蛋白（SHBG）产生的调节作用的比较研究。
2. Plasma sex hormone-binding globulin rather than corticosteroid-binding globulin is a marker of insulin resistance in obese adult males. [J] . Lewis JG, Shand BI, Elder PA, Diabetes, obesity & metabolism . 2004,第4期

机译：血浆性激素结合球蛋白而非皮质类固醇结合球蛋白是肥胖成年男性胰岛素抵抗的标志。
3. Longitudinal associations between sex hormone-binding globulin and insulin resistance [J] . Kristin Ottarsdottir, Margareta Hellgren, David Bock, Endocrine Connections . 2020,第5期

机译：性激素结合球蛋白和胰岛素抵抗之间的纵向关联
4. Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment [C] . Scott M. Kahn, Yu-Hua Li, Daniel J. Hryb, International Symposium on Hormonal Carcinogenesis . 2008

机译：性激素结合球蛋白影响LNCAP和MCF-7细胞的基因表达响应雄激素和雌激素治疗
5. Influence of insulin, insulin-like growth factor 1, and sex steroids on the regulation of the vitellogenin receptor in developing oocytes of largemouth bass (Micropterus salmoides). [D] . Dominguez, Gustavo. 2012

机译：胰岛素，类胰岛素生长因子1和性类固醇对大嘴鲈（Micropterus salmoides）发育卵母细胞卵黄蛋白原受体的调节的影响。
6. Does sex hormone-binding globulin cause insulin resistance during pubertal growth? [O] . Shenglong Le, Leiting Xu, Moritz Schumann, 2019

机译：性激素结合球蛋白会在青春期生长期间引起胰岛素抵抗吗？
7. The Biological Variation of Sex Hormone-Binding Globulin in Type 2 Diabetes: Implications for sex hormone-binding globulin as a surrogate marker of insulin resistance [O] . V. Jayagopal, E. S. Kilpatrick, P. E. Jennings, 2003

机译：2型糖尿病中性激素结合球蛋白的生物变异：性激素结合球蛋白的影响作为胰岛素抵抗的替代标记

Does sex hormone-binding globulin cause insulin resistance during pubertal growth?

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