Neonatal Meningitis by Multidrug ResistantElizabethkingia meningosepticumIdentified by 16S Ribosomal RNA Gene Sequencing

摘要

Clinical and microbiological profile of 9 neonates with meningitis byElizabethkingia meningosepticumidentified by 16S ribosomal gene sequencing was studied. All the clinical isolates were resistant to cephalosporins, aminoglycosides, trimethoprim-sulfamethoxazole,β-lactam combinations, carbapenems and only one isolate was susceptible to ciprofloxacin. All the isolates were susceptible to vancomycin. Six of nine neonates died even after using vancomycin, based on susceptibility results.E. meningosepticummeningitis in neonates results in high mortality rate. Though the organism is susceptible to vancomycin in vitro, its efficacy in vivo is questionable and it is difficult to determine the most appropriate antibiotic for treatingE. meningosepticummeningitis in neonates.