Infections by microorganisms, such as gram-positive and gram-negative bacteria, virus, fungi, and protozoa are major concerns in clinical and pharmaceutical areas (drugs, medical devices, and food industry (food packaging, storage, and fresh products)). New antimicrobial polymers were prepared by the reaction of 5,5-dimethylimidazolidine-2,4-dione, 5,5-diphenylimidazolidine-2,4-dione, 1-(2,5-dioxoimidazolidin-4-yl)urea, 5,5-diphenyl-2-thioxoimidazolidin-4-one and 5-benzylidene-imidazolidine-2,4-dione with 6-O-Tosyl-N-phthaloyl chitosan and reaction of 5,5-dimethylimidazolidine-2,4-dione, 5,5-diphenyl-2-thioxoimidazolidin-4-one and 5-benzylidene-imidazolidine-2,4-dione with O-succinoyl chitosan chloride. The reaction achieved by activation of hydroxyl groups on the C-6 position of glucosamine residues of chitosan. The structure of the resulting materials was characterized with Fourier transform infrared-spectroscopy, X-ray diffraction TGA analysis and transmission electron microscope. Antimicrobial activity of the polymers was studied against Gram-negative bacteria, Gram-positive bacteria by well diffusion method and cut plug method. Polymers showed good or moderate antimicrobial activities.
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