首页> 外文期刊>American Journal of Neuroscience >Green Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in Rats
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Green Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in Rats

机译:绿茶治疗可减轻大鼠脑出血实验模型引起的氧化损伤和神经运动障碍

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The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg-1) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our results show that ICH causes neuromotor deficits observed by Neurological Deficit Scale (NDS), Open Field (OF) and Rotarod (RR). GT treatment attenuates this deficit on day 3 for NDS and OF and on day 7 for RR. Also, ICH increases Reactive Oxygen Species (ROS) production and lipid peroxidation, what is not observed in ICH + GT group. Currently, there are no effective pharmacologic or non-pharmacologic neuroprotective treatments for ICH. Nutritional interventions that help on its outcome are important, since they are generally accessible and have few side effects.
机译:本研究显示了补充绿茶(GT;山茶)在大鼠脑出血(ICH)模型中的神经保护作用。雄性Wistar大鼠通过纹状体内胶原酶灌注诱导ICH。 ICH后通过管饲法给予GT(400 mg Kg-1)10天。我们评估了GT对神经运动恢复和氧化损伤的影响。我们的研究结果表明,ICH会导致神经功能缺损(NDS),开放视野(OF)和罗塔罗德(RR)观察到神经运动缺陷。 GT治疗在NDS和OF的第3天和RR的第7天减轻了这种不足。此外,ICH会增加活性氧(ROS)的产生和脂质过氧化,这在ICH + GT组中没有观察到。当前,没有针对ICH的有效药物学或非药物学神经保护疗法。营养干预对改善其结局非常重要,因为它们通常可以使用并且几乎没有副作用。

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