A genetic variant near TSLP is associated with chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease in Japanese populations

摘要

Chronic rhinosinusitis with nasal polyps (CRSwNP), is a heterog-enous disease associated with asthma, high degrees of diseaseseverity, and a poor quality of life. 1 Some patients with CRSwNPhave a specific condition called aspirin-exacerbated respiratory dis-ease (AERD) which is characterized by a triad of symptomsincluding CRSwNP, asthma, and sensitivity to non-steroidal anti-in-flammatory drugs (NSAIDs).