Anti-inflammatory and analgesic effects of coral reef associated gastropod, Trochus tentorium from Tuticorin coastal waters, Southeastern India

摘要

The aim of?this?work was to investigate extensively, the biomedical potential of the mollusc?Trochus tentorium?which are abundantly associated with coral reef of the Tuticorin coastal water. The 100% acetone fraction of the gastropod tested for its analgesic effect on Swiss mice model and anti-inflammatory activity on albino rat showed promising results.?T. tentorium?at the concentration of 25 and 50 mg/kg (p.o) showed significant decrease in the paw thickness (41.15 and 73.6%, respectively) at the 5th hour of the experiment. The 100% column-purified fraction of the?T. tentorium(200 mg/kg p.o) exhibited significant (p < 0.001) inhibition of 79.22% against acetic acid induced abdominal constrictions. The dose of 25 mg/kg showed the inhibitions inthe?writhings of 67.86% (p<0.001) of animals when compared to the standard (diclofenac sodium), and 56.83% (50 mg/kg) inhibition was observed. These facts suggest that?T. tentorium?is a potential source for anti-inflammatory and analgesic compounds.