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CONCEPT OF A FORMAL SYSTEM AIMED AT MODELLING BIOLOGICAL PROCESSES IN CELL

机译:用于模拟细胞生物过程的正式系统的概念

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In this paper a concept of a formal system aimed at modelling biological processes in cell is introduced. The aim of this formulation is to provide a theoretical basis for numerical simulations of the biological processes taking into account accessibility to various levels of details and possible full complexity of phenomena associated with them. The main segment of this formal system is a method of multiscale modelling called here the collection of dynamical systems with dimensional reduction. This approach allows one to integrate various mathematical methods applied in cell biology. It is especially related to continuum mechanics and molecular dynamics. Such a formal mathematical approach is supplemented by a set of notions which characterizes specific properties of biological systems. They are: the molecular recognition, integrity property for a chain of chemical reactions and molecular reactive structures. Nanoscale models of molecules are suggested to be a central segment of the multiscale modelling and are designed to direct cooperation with molecular dynamics. They are aimed at describing multimolecular processes in cell. It is shown that the nanoscale level of description is convenient for modelling molecular motors. Status of the present stage of formulation of the formal system is discussed taking into account further development directions.
机译:在本文中,引入了旨在模拟细胞中生物过程的正式系统的概念。该表述的目的是为生物过程的数值模拟提供理论基础,其中要考虑到各个级别细节的可及性以及与之相关的现象的可能的全部复杂性。该形式系统的主要部分是一种多尺度建模方法,在此称为具有降维的动态系统集合。这种方法使人们能够整合应用于细胞生物学的各种数学方法。它尤其与连续体力学和分子动力学有关。这种形式化的数学方法由一组表征生物系统特定特性的概念进行了补充。它们是:分子识别,化学反应链和分子反应性结构的完整性。分子的纳米级模型被认为是多尺度建模的核心部分,旨在直接与分子动力学合作。它们旨在描述细胞中的多分子过程。结果表明,纳米级的描述方便了分子电动机的建模。考虑到进一步的发展方向,讨论了形式系统制定当前阶段的状况。

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