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首页> 外文期刊>Clean >Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics
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Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics

机译：使用基于NMR的代谢组学研究镉在菲律宾蛤仔C中G的毒理学效应

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摘要

Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 μg L~(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24,48, and 96 h. Both low (10 μgL~(-1)) and high (40 (μgL~(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.
机译：镉已成为渤海沉积物和海水中重要的重金属污染物，并且由于其对海洋生物的毒性作用而具有极大的生态风险。在这项工作中，研究了环境相关浓度（10和40μgL〜（-1））的镉在马尼拉蛤仔菲律宾蛤仔exposure暴露24,48和96 h后的ill组织中引起的毒理作用。低（10μgL〜（-1））和高（40（μgL〜（-1））剂量的Cd都会引起能量代谢，渗透调节和神经毒性的紊乱，这些代谢基于琥珀酸，丙氨酸，支链等代谢生物标记物暴露24 h后蛤g中的氨基酸，甜菜碱，次牛磺酸和谷氨酸，但是暴露于96 h的蛤obviously中镉的毒理作用明显恢复，总体而言，这些结果表明基于NMR的代谢组学可用于阐明海洋生物指示剂中重金属污染物的毒理作用。

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  • 来源
    《Clean》 |2011年第11期|p.989-995|共7页
  • 作者

    Linbao Zhang; Xiaoli Liu; Liping You; Di Zhou; Junbao Yu; Jianmin Zhao; Jianghua Feng; Hulfeng Wu;

  • 作者单位

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China The Graduate School of Chinese Academy of Sciences, Beijing, R R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China The Graduate School of Chinese Academy of Sciences, Beijing, R R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China The Graduate School of Chinese Academy of Sciences, Beijing, R R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China The Graduate School of Chinese Academy of Sciences, Beijing, R R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China;

    Department of Electronic Science, Fujian Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, R R. China;

    Key Laboratory of Coastal Zone Environment Processes, CAS Shandong Provincial Key Laboratory of Coastal Zone Environment Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, P. R. China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomarker; cadmium; manila clam; metabolomics; toxicological effect;

    机译：生物标志物镉;马尼拉蛤代谢组学毒理作用;

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