Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats

摘要

AIM To explore the kinetic changes in plasma D(-)- lactate and lipopolysaccharide (LPS) levels, and investigate whether D(-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/ reperfusion, burn, and acute necrotizing pancreatitis (ANP). METHODS Three models were developed in rats: (1) gut Ischemia / reperfusion obtaine by one hour of superior Mesenteric artery occlusion followed by reperfusion; (2) Severe burn injury created by 30/100 of total body surface Area 9TBSA) full-thickness scald burn; and (3) ANP Induced by continuous inverse infusion of sodium Taurocholate and trypsin into main pancreatic duct.