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Safety and efficacy of a maternal vaccine for the passive protection of broiler chicks against necrotic enteritis

机译:母鸡疫苗被动预防肉鸡坏死性肠炎的安全性和有效性

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摘要

Necrotic enteritis is a potentially fatal multifactorial disease of chickens, which under commercial conditions is often associated with increased levels of mortality and reduced bird performance. The safety and efficacy of a Clostridium perfringens type A alpha-toxoid (Netvax™) formulated as an oil emulsion was investigated, following maternal immunization of broiler breeder hens, housed under commercial conditions, by the intramuscular route. A total of 11,234 hens were vaccinated across two integrated poultry sites. The vaccine was safe with no systemic reactions or adverse effects on bird performance detected. Vaccination resulted in a significant increase in anti-alpha toxin antibody in the hen that was maintained throughout the study, and subsequently transferred to their progeny throughout the laying period via egg yolk. Chicks hatched from eggs produced from vaccinated hens were shown to have reduced mortality specifically related to progeny flocks where gross gut lesions associated with necrotic enteritis were observed in control chicks. Further, whilst C. perfringens was isolated from control chicks with necrotic enteritis lesions, no such isolations were made at these time points from chicks from vaccinated hens. These results indicate that, under commercial conditions, maternal vaccination with Netvax™ can help to control losses related to necrotic enteritis.
机译:坏死性肠炎是一种潜在的致命性多因素鸡疾病,在商业条件下通常与死亡率增加和禽只性能下降有关。安全性和有效性的产气荚膜梭状芽孢杆菌α-类毒素(Netvax™)配制为油乳剂,在母体对商业条件下饲养的肉鸡进行母体免疫后,通过肌内途径进行了研究。在两个整合的家禽场共接种了11,234头母鸡。该疫苗是安全的,没有发现全身反应或对禽类性能有不利影响。疫苗接种使母鸡的抗α毒素抗体显着增加,并在整个研究过程中都得到了维持,随后在整个产蛋期通过蛋黄转移到它们的后代。从接种母鸡产生的卵中孵出的小鸡显示出降低的死亡率,这与后代鸡群特别相关,在对照小鸡中观察到与坏死性肠炎相关的大肠损伤。此外,虽然从具有坏死性肠炎病灶的对照雏鸡中分离出产气荚膜梭菌,但在这些时间点没有从接种母鸡的雏鸡中分离出产气荚膜梭菌。这些结果表明,在商业条件下,Netvax™的孕产妇疫苗接种可以帮助控制与坏死性肠炎有关的损失。

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  • 来源
    《Avian Pathology》 |2010年第6期|p.489-497|共9页
  • 作者

    C. F. Crouch; M. J. Francis;

  • 作者单位

    Intervet Schering-Plough Animal Health, Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK;

    Intervet Pharma R&D, Rue Olivier de Serres, Angers Technopoles, B.P. 67131, 49071, Beaucouzé Cedex, France;

    Clinical Research Monitor, 328 rue des Pyrénées, 750;

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