THE STUDY ON RELATION BETWEEN CD1A~+ CELLS AND INFILTRATIVE CD3~+ AND CD8+ CELLS IN RENAL TISSUE OF GLOMERULONEPHRITIS

摘要

Objective To discuss the role of dendritic cells (DCs) in cellular immunity pathogenesis of glomerulonephritis (GN). Methods 114 patients with GN were selected randomly and divided into two groups, primary GN (pGN) and secondry GN (sGN). CD1a~+, CD3~+ and CD8~+ ceils in bioptic renal tissues were examined immunohistochemically. The distribution of CD1a+ cells and the infiltration of CD3+ and CD8+ cells in renal tissues were observed. Results There was no significant difference of CD1a~+, CD3+ , and CD8+ cells between pGN and sGN group (P>0. 05). CD1a+ cells had significant positive correlation with the infiltrative CD3+ and CD8+ cells, respectively (P<0. 01). The infiltrative CD3+ cells had significant positive correlation with the CD8+ cells in the same area, respectively (P<0. 01). CD1a+ cells, CD3+ cells infiltrating in both glomeruli and renal interstitial tissues, and CD8+ cells only infiltrating in renal interstitial tissues, all of them had significant positive correlation with the degree of glomerular proliferation, respectively (P<0. 05). The infiltrative CD3~+ and CD8~+ cells in renal interstitial tissues had significant positive correlation with the degree of glomerular sclerosis and the lesion degree of renal tubule and interstitial, respectively (P<0. 05). There were significant positive correlation between CD1a~+ cells and the lesion degree of renal interstitial (P<0. 05). Conclusion DCs could activate T lymphocyte by presenting antigen, then the activated T lymphocyte participate in the pathogenesis of GN through releasing cytokine and/or directly damaging the renal tubule and interstitial, which produce more serious glomerular lesion.