Complete-Proteome Mapping of Human Influenza A Adaptive Mutations:Implications for Human Transmissibility of Zoonotic Strains

摘要

BackgroundThere is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale comparative analysis of proteins from avian and human strains, to produce a catalogue of mutations associated with H2H transmissibility, and to detect their presence in avian isolates.