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Stroke Risk among Patients with Type 2 Diabetes Mellitus in Zhejiang: A Population-Based Prospective Study in China

机译:浙江省2型糖尿病患者的中风风险:基于人群的中国前瞻性研究

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摘要

Objective. This study aimed to explore the incidence of stroke and stroke subtypes among patients with type 2 diabetes mellitus (T2DM) based on the long-term surveillance data in Zhejiang, China, during 2007 to 2013. Materials and Methods. During January 1, 2007, and December 31, 2013, a total of 327,268 T2DM and 307,984 stroke patients were registered on Diabetes and Stroke Surveillance System, respectively. Stroke subtypes were classified according to standard definitions of subarachnoid hemorrhage, intracerebral hemorrhage, and ischemic stroke. The incidence of stroke and stroke subtypes was calculated by standardized incidence ratio (SIRs) with 95% confidence intervals (CIs) compared with general population. Results. The incidence of stroke and stroke subtypes among patients with T2DM was significantly higher than in general population. Stroke risk was found significantly increased with an SIR of 3.87 (95% CI 3.76–3.99) and 3.38 (95% CI 3.27–3.48) in females and males, respectively. The excess risk of stroke was mainly attributable to the significantly higher risk of cerebral infarctions with the risk for T2DM being four times that for general population. Conclusions. The relationship between stroke and T2DM was strong, especially in female. The incidence of stroke and stroke subtypes among patients with T2DM was up to 3-fold higher than in general population in Zhejiang province, especially the subtype of cerebral infarctions.
机译:目的。本研究旨在根据2007年至2013年中国浙江省的长期监测数据,探讨2型糖尿病(T2DM)患者中风和中风亚型的发生率。材料和方法。在2007年1月1日和2013年12月31日,分别有327,268例T2DM和307,984例中风患者在糖尿病和中风监护系统上进行了注册。中风亚型根据蛛网膜下腔出血,脑内出血和缺血性中风的标准定义进行分类。中风和中风亚型的发生率是通过与普通人群相比具有95%置信区间(CI)的标准化发生率(SIR)来计算的。结果。 T2DM患者中风和中风亚型的发生率显着高于普通人群。女性和男性的中风风险显着增加,SIR分别为3.87(95%CI 3.76–3.99)和3.38(95%CI 3.27–3.48)。中风的额外风险主要归因于脑梗塞的风险明显更高,T2DM的风险是普通人群的四倍。结论。中风和T2DM之间的关系很强,尤其是女性。 T2DM患者中风和中风亚型的发生率比浙江省普通人群高3倍,尤其是脑梗死的亚型。

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