MicroRNA-34a and vascular senescence in diabetes

摘要

Diabetes is a prominent chronic condition characterized by increased glycemic levels due to either loss of insulin production (type I diabetes, T1D) or impaired insulin sensitivity (type II diabetes, T2D). A major target of diabetes is the vasculature and virtually all diabetic complications are associated with macro- and micro-vascular alterations. Therefore, the deleterious impact of hyperglycemia on the vascular endothelium represents the main cause of morbidity and mortality in diabetes.