A Composite Model of Glucagon–Glucose Dynamics for In Silico Testing of Bihormonal Glucose Controllers

摘要

Background:The utility of simulation environments in the development of an artificial pancreas for type 1 diabetes mellitus (T1DM) management is well established. The availability of a simulator that incorporates glucagon as a counterregulatory hormone to insulin would allow more efficient design of bihormonal glucose controllers.Existing models of the glucose regulatory system that incorporates glucagon action are difficult to identify without using tracer data. In this article, we present a novel model of glucagon–glucose dynamics that can be easily identified with standard clinical research data.