Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice

摘要

Kisspeptin is distributed in brain areas regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1 and 3µg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50%, 95% and 90% respectively during the 2–3 h period post injection. The 1µg/mouse dose reduced the 4-h cumulative food intake by 28% while intraperitoneal injection (10µg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (−45%/4h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.