In Women with Symptoms of Cardiac Ischemia Non-Obstructive Coronary Arteries and Microvascular Dysfunction ACE Inhibition is Associated with Improved Microvascular Function: A Double-blind Randomized Study from the NHLBI Women’s Ischemia Syndrome Evaluation (WISE)

摘要

BackgroundWe investigated the role of the renin-angiotensin system in women with signs and symptoms of ischemia without obstructive coronary artery disease (CAD). Although microvascular dysfunction has been suggested to explain this syndrome and recently was found to predict adverse outcomes, the mechanisms and treatments remain unclear.