Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway and impairs cholesterol efflux

摘要

ObjectiveEndosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis. Accumulation of BMP is a hallmark of lipid storage disorders and was recently reported as a noticeable feature of oxidized LDL-laden macrophages. This study was designed to delineate the consequences of macrophage BMP accumulation on intracellular cholesterol distribution, metabolism and efflux and to unravel the underlying molecular mechanisms.