Influence of glutathione‐S‐transferase (GSTM1 GSTP1 GSTT1) and cytochrome p450 (CYP1A1 CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome

摘要

BackgroundThe naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant multisystem disorder with variable expression. NBCCS patients have variable susceptibility to development of basal cell carcinoma (BCC). Previous studies have shown that polymorphisms of some metabolic genes encoding the cytochrome p450 (CYP) and glutathione‐S‐transferase (GST) enzymes influenced the numbers of BCCs in sporadic BCC cases.