3D-QSAR and 3D-QSSR studies of thieno23-dpyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis

摘要

Aim:To investigate the structural basis underlying potency and selectivity of a series of novel analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones as cyclin-dependent kinase 4 (CDK4) inhibitors and to use this information for drug design strategies.