Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome

摘要

BackgroundThe Lundehund is a highly specialized breed characterized by a unique flexibility of the joints and polydactyly in all four limbs. The extremely small population size and high inbreeding has promoted a high frequency of diseased dogs affected by the Lundehund syndrome (LS), a severe gastro-enteropathic disease.