A model invalidation-based approach for elucidating biological signalling pathways applied to the chemotaxis pathway in R. sphaeroides

摘要

BackgroundDeveloping methods for understanding the connectivity of signalling pathways is a major challenge in biological research. For this purpose, mathematical models are routinely developed based on experimental observations, which also allow the prediction of the system behaviour under different experimental conditions. Often, however, the same experimental data can be represented by several competing network models.