Index sites of breast and cervix uteri were selected from populationbased data held at the West Midlands and Birmingham Regional Cancer Registry, and the expected numbers of second primary cancers in cervix and breast were computed (sequence analyses). In the breast series (17,756 patients) a small deficit of cervical tumours was observed (O = 16, E = 2·119, O/E = 0·76, P > 0·05), while in the cervix series (4817 patients) a small excess of breast tumours was found (O = 29, E = 23·38, O/E = 1·24, P > 0·05) over a period of 15 years.A theoretical statement of the combined risk of the 2 tumours occurring in the same individual of a general population was developed and was compared with the practical approach of summing the sequence analyses (complementary analysis). Complementary analysis indicated that there was no excess of women with the 2 primary tumours (O = 45, E = 44·57, O/E = 1·01) and that cancers of the breast and cervix uteri are not aetiologically related.
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机译:从西米德兰兹郡和伯明翰地区癌症登记处收集的基于人口的数据中选择了乳腺癌和子宫颈的指标位点,并计算了子宫颈和乳腺癌中第二原发癌的预期数量(序列分析)。在乳腺系列(17,756例患者)中观察到少量宫颈肿瘤(O = 16,E = 2·119,O / E = 0·76,P> 0·05),而在子宫颈系列(4817例患者) )在15年的时间内发现了少量过量的乳腺肿瘤(O = 29,E = 23·38,O / E = 1·24,P> 0·05)。开发了在普通人群的同一个体中发生的2种肿瘤,并将其与总结序列分析(互补分析)的实用方法进行了比较。补充分析表明,有两种原发性肿瘤的女性不多(O = 45,E = 44·57,O / E = 1·01),并且乳腺癌和子宫颈癌的病因学无关。
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